Having available a realistic digital model of a human would provide in many ways tremendous benefits, e.g. it certainly would constitute a quantum leap in personalised healthcare. This grand vision is shared between many researchers worldwide including the Cluster of Excellence for Simulation Technology (SimTech) at the University of Stuttgart through SimTech’s “Overall Human Model” vision. With this proposal, we want to contribute to this grand vision by developing realistic models of the neuromuscular system. This poses not only significant modelling and computational challenges, but also challenges in visualising the simulation results.