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DTSTAMP:20160706T122554
UID:85ba8b30-cc7e-11e8-806c-000e0c3db68b
SUMMARY:Vortrag | Annette Birkhold, Institut für Mechanik, Universität Stuttgart
DESCRIPTION:Abstract:\nAge-related diseases, such as age-related bone loss and osteoporosis, are a major challenge in\nour aging society. Bone is a constantly (re)modeling organ, dynamic processes repeatedly modify its\nmicrostructure throughout life. In these processes, existing bone material is removed and replaced\nby newly formed new bone packages. Besides this ability to restructure, bone has the potential to\nadapt its mass and micro-structure to changes in its mechanical environment, to maintain its\nload-bearing efficiency and consequently to avoid mechanical failure. Due the dynamic\ncharacteristics of the bone restructuring processes, a method has to include the kinetics of these\nprocesses into the evaluation of bone (re)modeling. However, to date retrospective 2D manual\ntechniques are mainly used to analyze bone remodeling. These methods do not allow for a combined\ndirect spatio-temporal investigation of bone (re)modeling events as well as sequences, enabling the\nmonitoring of dynamic bone restructuring over time. Thus, a concept for including the\nspatio-temporal character of bone (re)modeling into the analysis of bone health has to be developed\nand applied to more precisely answer specific biological bone research questions. Therefore, a\nframework has developed, including registration, segmentation, feature extraction, tracking and\nanalysis methods, enabling an in depth evaluation of dynamic changes in bone structure. Using this\nmethod, longitudinal microCT data sets of bone acquired in experimental bone biology can be\nevaluated such that bone formation and resorption processes, as well as the overall (re)modeling\nsequences can be detected, displayed and morphologically quantified. Automated 3D methods have a\ngreat potential to improve the basic knowledge of the body and the diagnosis of patho-physiological\nconditions in the individual in the near future. The development, design, validation and first\napplications of a tomography-based medical image processing method and tool for enhanced\nvisualization and quantification of patho-physiological dynamic structural processes in bone is\npresented, representing a step in the direction of a holistic, automated analysis of bone and\nproviding new insights into dynamic micro-structural processes. The developed method and tool were\nvalidated and applied to answer specific biological research questions. Application of the\ndeveloped method in several studies enabled the evaluation of quantitative (re)modeling differences\non different bone surfaces. Linking this information of formation and resorption processes of all\nbone surfaces, the trabecular, the endocortical and the periosteal, enabled a detailed 3D\ntime-dependent analysis of the structural dynamics and thereby allowing, for the first time, a\nprecise quantification of the whole balances of bone restructuring. Taken together, it could be\nshown that it is possible to extract spatial as well as temporal information of dynamic bone\nrestructuring processes using computational image analysis methods that are integrated in an\nexisting experimental imaging setup using a commercially available microCT device. This constitutes\na new approach to establish a more complete analysis of bone (re)modeling in experimental biology\nand provides the basis for an early risk detection and intervention of bone loss in human\npatients.\nSpeaker's Bio:\n2003-2010: Maschinenbau-Studium Uni Stuttgart\n2010-2014: PhD student: TU Berlin & Julius Wolff Institut (Charité – Universitätsmedizin\nBerlin) & Berlin Brandenburg School for Regenerative Therapies\n2014-current: Post-doc: Continuum Biomechanics and Mechanobiology Group, Institut für Mechanik,\nUni Stuttgart 
DTSTART:20160701T100000
LOCATION:VISUS, Campus Vaihingen, Raum -01.116 (Powerwall), Allmandring 19, 
URL;VALUE=URI:https://www.vis.uni-stuttgart.de/aktuelles/veranstaltungen/Vortrag-Annette-Birkhold-Institut-fuer-Mechanik-Universitaet-Stuttgart/
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